Tag Archives: Renal function

How the Body Handles Drugs USING Kidney and Liver-INTERESTING FACT

Concentrations of Drugs in the Blood are a Balance Between Input and Output

  • The concentrations of all chemicals in your body are the result of a balance between input and output.
  • For drugs the input is usually a steady injection through an intravenous (IV) line or a periodic uptake through pills taken at regular intervals.
  • The output of drugs is mainly through 2 organs, the liver and kidney.
  • When the output equals the input a steady-state is attained and the concentration will no longer change:


Section of cortex of human kidney.

Image via Wikipedia

Basic Kidney Anatomy

  • Kidneys paired, about 150 gm each
  • Urine forming units:
    • Cortex
    • Medulla (lobed: renal pyramids)
    • Cortex and medulla composed chiefly of nephrons and blood vessels
    • Supplied by renal arteries (branches of descending aorta) and renal veins (branches of inferior vena cava)
  • Urine collecting and expelling units:
    • Calyces
    • Renal pelvises
    • Ureters
    • Bladder
    • Urethra

Although the Kidneys are Tiny Organs They Receive 25% of the Cardiac Output