Researchers from Rice University and Baylor College of Medicine (BCM) have broken one of the major roadblocks on the path to growing transplantable tissue in the lab: They’ve found a way to grow the blood vessels and capillaries needed to keep tissues alive.
The new research is available online and due to appear in the January issue of the journal Acta Biomaterialia (“Covalently immobilized platelet-derived growth factor-BB promotes angiogenesis in biomimetic poly(ethylene glycol) hydrogels “). “The inability to grow blood-vessel networks — or vasculature — in lab-grown tissues is the leading problem in regenerative medicine today,” said lead co-author Jennifer West, department chair and the Isabel C. Cameron Professor of Bioengineering at Rice. “If you don’t have blood supply, you cannot make a tissue structure that is thicker than a couple hundred microns.”
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