PhD: To develop a Microneedle-based Sampling Device of Analysis of Interstitial Fluids
A PhD position is available immediately in the area of microneedle-facilitated physiological monitoring.
Microneedle arrays consist of a number of short (0.1-0.5mm) projections that are sharp and robust enough to penetrate the outer layers of human skin. Since their length can be such that they do not stimulate nerve cells deeper within the skin layers, the use of these arrays is painless. Microneedles that incorporate a hollow capillary tube may be used to withdraw small volumes of interstitial fluid (i.e. the fluid that occupies the spaces between cells) from the skin; this fluid contains a range of biomarkers which may be used to indicate wellbeing. This PhD position will primarily focus on the development of a microneedle-based sampling interface, to be integrated with devices already under development for enabling microfluidic actuation, optical detection, and sample analysis within a fully automated microsystem.
Tyndall is a world leader in the design and application of silicon-based microneedle technologies, and the successful candidate will contribute to the development of a microneedle-based sensing system for sampling and analysis of interstitial fluids.
Candidates with a 1st Class Honors primary degree in Biomedical Engineering, Microsystems Technologies, Engineering and closely related fields are invited to apply for this position. A higher degree such as an M.Sc. will be an advantage; as will an excellent knowledge of bioMEMS, demonstratable experimental skills and a desire to apply these talents to understanding the operation of new devices. The successful candidate should be highly motivated with excellent organizational and communications skills. This position offers an excellent opportunity to work within a multidisciplinary group, on a commercially relevant field of biomedical research. As the project is run in close association with the SFI-funded CLARITY Centre for Science, Engineering and Technology (www.clarity-centre.org), collaboration with related activities in University College Dublin (UCD) and Dublin City University (DCU) are envisaged.
The candidate will work within a large multidisciplinary group, and be responsible for
- Development of the system, including microneedle and sensor system specification,
- Supervision of the necessary manufacturing processes and system assembly;
- Integration of the microneedle devices with a fluidic control module;
- Performing the characterisation and pre-clinical validation of the devices and system;
- Contributing to and/or initiation of peer reviewed scientific publications as appropriate;
- Working with collaborating researchers within Tyndall, in DCU and UCD as applicable
- Presentation of technical results and project updates at project meetings;
- Assisting senior researchers in completing project deliverables.
Further details can be obtained from Dr. Paul Galvin (paul.galvin@tyndall.ie) or Dr. Conor O’Mahony (conor.omahony@tyndall.ie).
To apply, please submit your CV to careers@tyndall.ie quoting the reference number.
Tyndall National Institute is an Equal Opportunities Employer.
