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The Graduate School at IST Austria invites applicants from all countries to its PhD program. IST Austria is
a new institution located on the outskirts of Vienna dedicated to cutting-edge basic research in the natural
sciences and related disciplines. The language at the Institute and the Graduate School is English.
The PhD program combines advanced coursework and research, with a focus on Biology, Computer Science,
Neuroscience, and interdisciplinary areas. IST Austria offers internationally competitive PhD salaries supporting 4-5 years
of study. Applicants must hold either a BS or MS degree or equivalent.
The Institute offers PhD students positions with the following faculty:
Researchers characterize biomechanics of ovarian cells in mice according to their phenotype at early, intermediate, and late-aggressive stages of cancer
Using ovarian surface epithelial cells from mice, researchers from Virginia Tech have released findings from a study that they believe will help in cancer risk assessment, cancer diagnosis, and treatment efficiency in a technical journal:Nanomedicine.
By studying the viscoelastic properties of the ovarian cells of mice, they were able to identify differences between early stages of ovarian cancer and more advanced and aggressive phenotypes.
Image via Wikipedia
Promotor: Maurilio Sampaolesi
Description: Testing drugs for the effect on heart muscle contraction in a high-throughput fashion has been hampered so far because human cardiomyocytes are hard to culture. Current methods either use single cells or animal experiments. The aim of this project is to create contractile cardiac tissue by tissue-engineering. Induced pluripotent stem cells will be used to create cardiomyocytes, since these provide a renewable source. Next, these cardiomyocytes can be tissue-engineered in bio-artifial cardiac muscle. Use of such cardiac muscle will open the path to a new way of measuring contractile force and rhythm. This approach opens the path towards a novel platform for (patient-specific) drug screening and can provide insights in cardiac development and function.
Research techniques will encompass (stem) cell culture, tissue engineering, Q-PCR, immunohistochemistry, image analysis and a flavor of biological data intelligence.
Cancer cells photographed by camera attached to microscope in time-lapse manner. Image via Wikipedia
The upside of chemotherapy is that it attacks cancer cells and kills them. The downside – and a steep downside it is – is that it is composed of highly toxic compounds that attack other cells of the body, too, resulting in any number of harmful side effects, from anemia to hair loss to nausea and vomiting.
The question concerning researchers is how do we deliver chemotherapy drugs to the harmful cells and leave the healthy cells alone?
What sounds like science fiction is actually possible: thanks to magnetic stimulation, the activity of certain brain nerve cells can be deliberately influenced. What happens in the brain in this context has been unclear up to now. Medical experts from Bochum under the leadership of Prof. Dr. Klaus Funke (Department of Neurophysiology) have now shown that various stimulus patterns changed the activity of distinct neuronal cell types. In addition, certain stimulus patterns led to rats learning more easily. The knowledge obtained could contribute to cerebral stimulation being used more purposefully in future to treat functional disorders of the brain. The researchers have published their studies in the Journal of Neuroscience and in the European Journal of Neuroscience.