Author Archives: biomedin

LECTURE NOTES ON QUANTITATIVE PHYSIOLOGY

COURSE DESCRIPTION

Human systems physiology, including:  basic cellular physiology, neuromuscular, cardiovascular, respiratory, renal and gastro-intestinal physiology.  A quantitative, model-oriented approach to physiological systems is stressed.

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Color / Full Page Slides (PDF Format) Printable (6 slides per page, black and white) Slides (PDF Format) Slides in Powerpoint (ppt) Format
1 Lecture 1 Lecture 1 Lecture 1
2 Lecture 2 Lecture 2 Lecture 2
3 Lecture 3 Lecture 3 Lecture 3
4 Lecture 4 Lecture 4 Lecture 4
5 Lecture 5 Lecture 5 Lecture 5

DNA & Heredity Transcription & Translation

Protein Synthesis Involves Transcription & Translation

  • The 2 steps of protein synthesis:
    Process Where Major Components Notes
    Transcription In the nucleus DNA gene
    RNA polymerase
    Gene is activated.
    A copy of the code is made from RNA (m-RNA)
    m-RNA leaves the nucleus, goes to cytoplasm.
    Translation In the cytoplasm, on the ribosomes m-RNA
    Ribosomes
    Peptidyl transferase enzyme
    Transfer RNAs
    Ribosome decodes the m-RNA and makes the correct protein.
  • Keeping the main copy of the genes in the nucleus protects it from damage
  • There are many DNA repair mechanisms in the nucleus

DNA, RNA & Heredity Genetic Code

Information is Stored in the Code Letters of DNA

  • All hereditary information is stored in genes, which are parts of giant DNA molecules
  • Genes code for the amino acids of proteins
  • DNA is the archival copy of the code- kept in nucleus where it is protected & repaired
  • DNA is organized with special proteins into chromosomes
  • For protein synthesis a working copy of the code is made from RNA
  • Overall scheme: DNA -> RNA -> protein
  • Another version: “One gene, one enzyme”

The Code is Based Upon the Structure of DNA

CELL DIVISON

Reasons for Cell Division

  • Cell division is required for:
    • a) growth
    • b) repair & replacement of damaged parts
    • c) reproduction of the species

In Cell Division Copies of the DNA Must Be Sent to Both New Cells

  • Since the instructions for making cell parts are encoded in the DNA, each new cell must get a complete set of the DNA molecules
  • This requires that the DNA be copied (replicated, duplicated) before cell division

Genetic Blueprints for Cells Are Organized Into Chromosomes

  • The plans for making cells are coded in DNA

Cells: Structure & Function

All Living Organisms are Made Up of Units Called Cells

  • Cell theory:
    • All living creatures are made from 1 or more cells
    • All cells are produced from previously existing cells (no spontaneous generation)
  • All cells appear to be descended from the first cell which existed about 4 billion years ago
  • For a species to exist its reproductive cells must be potentially immortal (no aging)
  • Our bodies start from a single cell and contain about 100,000,000,000,000 (10^13) cells at maturity

There Are 2 Basic Types of Cells: Prokaryotic and Eukaryotic

LECTURE NOTES ON MEDICAL ELECTRONICS

1. Introduction to Medical Electronics

2. Coupling mechanisms of external noise